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Preliminary studies found honey to contain an antimicrobial peptide called bee defensin-1.Some in vitro studies show that honey can kill Methicillin-resistant Staphylococcus aureus (MRSA), β-haemolytic streptococci and vancomycin-resistant Enterococc

Although honey is generally safe when taken in typical food amounts,there are various, potential adverse effects or interactions it may have in combination with excessive consumption, existing disease conditions or drugs. Included among these are mild reactions to high intake, such as anxiety, insomnia or hyperactivity in about 10% of children, according to one study. No symptoms of anxiety, insomnia or hyperactivity were detected with honey consumption compared to placebo, according to another study. Honey consumption may interact adversely with existing allergies, high blood sugar levels (as in diabetes), or anticoagulants used to control bleeding, among other clinical conditions.