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Physiology of Hemopoietic System
The roots of Hemopoietic system are explained to be Liver and Spleen (Ca.Vi. 5/8). Role of liver and spleen in the functioning of hemopoietic system is very important. RBC synthesis occurs in liver and spleen in between 3rd and 5th month of intrauterine life. Liver stores some important hemopoietic factors like Vitamin B-12, folic acid and iron. It produces many clotting factors also. Cells of monocyte-macrophage system destroy RBCs in the spleen after they complete their life span.
Role of Bone Marrow
In the cavities of larger bones ‘Majjā’ is present whereas in the smaller ones it is ‘Sarakta Meda’(Su. Śā. 4/10). This ‘Sarakta Meda’ is indicative of Red bone marrow.
Formation of Bilirubin
Byproduct of metabolism of ‘Rakta’ is ‘Pitta’.(Ca. Ci. 15/18). This ‘Pitta’ is Bilirubin, the product of hemoglobin metabolism. This is formed in the monocytemacrophage system, mainly in the spleen.
When the ‘Pitta’ exceeds its normal levels, there is manifestation of symptoms like yellowish discoloration of feces, urine, eyes and skin (A.H. Sū. 11/7). When the total serum bilirubin level exceeds 2mg/dl, usually there is manifestation of clinical jaundice.