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Chemotactic drug-targeting
A special, reversal form of drug delivery where modulation of active migratory behaviour of the target cells is used to achieve targeted effects.[1] The general components of the conjugates are designed as follows: (i) carrier – regularly possessing promoter effect also on internalization into the cell; (ii) chemotactically active ligands acting on the target cells; (iii) drug to be delivered in a selective way and (iv) spacer sequence which joins drug molecule to the carrier and due to it enzyme labile moiety makes possible the intracellular compartment specific release of the drug.
