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Principal constituents of leaf, barks of stems and roots are indole alkaloids, picrinine, nareline, akuammicine, scholarine, strictamine, tetrahydroalastonine, detamine, echitenine, echitamine, ditamine, echitamidine, stigmasterol, ß-sitosterol, campesterol, flavanols, a- & ß-amyrin, lupeol, lupeol acetate and phenolic acids. Fresh leaves also contain five alkaloids, including nareline, akuammidine, picralinal, picrinine and ?-akuammigine. Stem bark contains echitamine, a glycoside of venoterpine, sterols, ß-sitosterol, triterpenes, saponins, lactones, a-amyrin acetate. Bark has also been reported to contain a blood sugar reducing agent.<ref name="chemical compositionChemical Composition"/>